@article { author = {Sabbour, Magda}, title = {Bioactivity of some regular and Nano encapsulated essential oils against C. maculatus and C. chinensis}, journal = {DYSONA - Life Science}, volume = {1}, number = {3}, pages = {96-101}, year = {2020}, publisher = {E-NAMTILA}, issn = {2708-6291}, eissn = {2708-6291}, doi = {10.30493/dls.2020.239285}, abstract = {Callosobruchus maculatus (Cowpea weevil) and Callosobruchus chinensis (Bean weevil) are among the important pests of stored seeds. These insects are usually controlled by harmful insecticides. Essential oils are considered a safe substitute in controlling stored products pests. In this work, the Nano-encapsulation technique was used to enhance the effectiveness of three types of essential oils (Mentha piperita “Peppermint”, Coriandrum sativum “coriander”, and Laurus nobilis “sweet bay”). The effectiveness of both regular and Nano oils was evaluated for their insecticidal activities against the third-instar larvae of C. maculatus and C. chinensis at a concentration of 0.5%. Additionally, the ovipositional activity inhibitory effects of Nano granules were evaluated using by mixing Nano granules with cowpea at a rate of 0.5%. Furthermore, the persistent effect of Nano encapsulated oils was evaluated after 90 days in storage. The repellent effect of Nano granules was also evaluated using the arena choice test method. The highest mortality rates of both C. maculatus and C. chinensis after 7 days of 0.5% treatment were observed in M. piperita, followed by C. sativum and Laurus nobilis in both regular and Nano oils. A significant increase in the larvicidal effect in C. sativum Nano granules in comparison to its regular oil was noticed. The results indicated that both C. maculatus and C. chinensis life cycles were heavily affected by Nano granules treatments of the three tested Nano granules with M. piperita Nano granules having the highest impact. The lowest weight loss in stored cowpea was observed under M. piperita Nano granules treatment especially against C. maculatus (3%) compared to control treatment (50%). The highest repellent effect was observed under C. sativum treatment against C. chinensis (88%). These results are highly promising and show the potentials of these oils and their Nano derivatives in stored products integrated pest management.}, keywords = {Cowpea weevil,Bean weevil,Mentha piperita,Laurus nobilis,Coriandrum sativum,Nano}, url = {https://life.dysona.org/article_113052.html}, eprint = {https://life.dysona.org/article_113052_f1ac583f15b7da94eea231399ecb2995.pdf} } @article { author = {Gupta, Sneha and Sherikar, Abdullah and Upaganlawar, Aman and Upasani, Chandrashekhar}, title = {Neuroprotective effects of α-Lipoic acid alone and in combination with ferulic acid in diabetic neuropathy induced rats}, journal = {DYSONA - Life Science}, volume = {1}, number = {3}, pages = {102-112}, year = {2020}, publisher = {E-NAMTILA}, issn = {2708-6291}, eissn = {2708-6291}, doi = {10.30493/dls.2020.243982}, abstract = {The present pre-clinical activity was undertaken to screen the two antioxidants, mainly α-lipoic acid and ferulic acid alone, and in combination in neuropathic pain induced by diabetes in rats. The activity was confirmed by assessing various behavioral as well as biochemical and histopathological studies. The study was performed on adult albino rats. The rats were divided into different groups, and each group contained six rats. Diabetic neuropathy in rats was induced by administering a freshly prepared single dose of streptozotocin (60 mg/kg, i.p). After the development of neuropathy, three groups were treated with α-lipoic acid (25 mg/kg/day, p.o), ferulic acid (10 mg/kg/day, p.o), or the standard drug Pregabalin (30 mg/kg/day i.p). The final group received a combination of antioxidants, (α-lipoic acid and ferulic acid) at 12 and 5 mg/kg, p.o, respectively, for two weeks. Neuropathic pain was assessed using mechanical allodynia, mechanical hyperalgesia, cold allodynia, and thermal allodynia. Biochemical parameters of blood glucose, nitric oxide, level of lipid peroxidase, reduced glutathione, and membrane-bound ATPase activities were also studied. Neuropathic pain-induced rats showed a significant alteration in behavioral and biochemical parameters. Treatment with α-lipoic acid in combination with Ferulic acid significantly restored the altered parameters towards normal as compared to single antioxidants, thus providing proper neuroprotection. This effect might be due to the strong free radical scavenging potential of α-lipoic acid and ferulic acid.}, keywords = {neuropathic pain,α-lipoic acid,ferulic acid,oxidative stress,Streptozotocin}, url = {https://life.dysona.org/article_114609.html}, eprint = {https://life.dysona.org/article_114609_e831c004dace07067f2c4db6511243b3.pdf} }