@article { author = {Khan, Safir and Khan, Munir}, title = {Molecular developments in cell models of fatty liver disease}, journal = {DYSONA - Life Science}, volume = {3}, number = {1}, pages = {16-29}, year = {2022}, publisher = {E-NAMTILA}, issn = {2708-6291}, eissn = {2708-6291}, doi = {10.30493/dls.2022.325915}, abstract = {Fatty liver is the second most widespread liver disease after viral hepatitis. The incidence of fatty liver is increasing, and the age of fatty liver is getting younger, which is a severe threat to human health. The fatty liver consists of a series of pathological symptoms like cirrhosis and hepatocellular carcinoma that may lead to fatty hepatitis as the disease progresses. Generally speaking, fatty liver belongs to reversible disease, through early diagnosis and timely treatment often can return to normal. Therefore, it is critical to understand the pathophysiology of fatty liver disease through cell models. In this review article, the three most commonly used cell models types(primary hepatocytes, immortal cells lines, hepatocyte-like cells from stem cells, and precision-cut liver slices), the three cell culture modes (monoculture, co-culture, and three-dimensional culture), and modeling method (high-Fat, high-sugar, and alcohol) have been summarized and analyzed. It will serve as a reference for fatty liver disease research and drug screening. }, keywords = {non-alcoholic fatty liver disease,Alcoholic fatty liver disease,Cell lines,Cell model}, url = {https://life.dysona.org/article_144934.html}, eprint = {https://life.dysona.org/article_144934_6fc02fc06077dc45f81bdf6023c79d79.pdf} }